The German-speaking states of the early modern period (c. 1500–1800) were divided politically and religiously. Religious tensions between the states comprising the Holy Roman Empire had existed during the preceding period of the Late Middle Ages (c. 1250–1500)—notably erupting in Bohemia with the Hussite Wars (1419–1434). However, the defining religious movement of this period, the Reformation, would result in unprecedented levels of violence and political upheaval for the region.

Usually considered to have begun with the publication of the Ninety-five Theses (1517) by Martin Luther in the city of Wittenberg (then within the Electorate of Saxony, now located within the modern German state of Saxony-Anhalt), the progression of the Reformation would divide the German states among new religious lines: the north, the east, and many of the major cities—Strasbourg, Frankfurt, and Nuremberg—becoming Protestant while the southern and western regions largely remained Catholic. Compromises and reforms would be made in an effort to promote internal stability within the Holy Roman Empire, importantly with the Peace of Augsburg in 1555, but these efforts would ultimately fall short and culminate in one of the most destructive conflicts the European continent had yet seen, the Thirty Years' War (1618–1648) which ended with the adoption of the incredibly consequential Peace of Westphalia.

Germany in the early modern period

This period also saw the emergence of the Kingdom of Prussia as the primary competitor to the previously hegemonic Habsburg monarchy. After the close of early modern period in Europe following the Age of Enlightenment and the dissolution of the Holy Roman Empire in 1806 during the Napoleonic Wars, this Austria-Prussia rivalry would prove to be the driving internal force behind the Unification of Germany in 1871.

Germany in the early modern period

The 16th century

German Renaissance

The German Renaissance, part of the Northern Renaissance, was a cultural and artistic movement that spread among German thinkers in the 15th and 16th centuries, which originated with the Italian Renaissance in Italy. This was a result of German artists who had traveled to Italy to learn more and become inspired by the Renaissance movement. Many areas of the arts and sciences were influenced, notably by the spread of humanism to the various German states and principalities. There were many advances made in the development of new techniques in the fields of architecture, the arts, and the sciences. This also marked the time within Germany of a rise of power, independent city states, and spread of Franciscan humanism.

Germany in the early modern period

German Reformation

The German Reformation initiated by Martin Luther led to the German Peasants' War in 1524–1525. Luther, along with his colleague Philipp Melanchthon, emphasized this point in his plea for the Reformation at the Imperial Diet of 1529 amid charges of heresy, but the edict by the Diet of Worms (1521) prohibited all innovations. With efforts to be understood as Catholic reformer as opposed to a heretical revolutionary, and to appeal to German princes with his religious condemnation of the peasant revolts backed up by the Doctrine of the Two Kingdoms, Luther's growing conservatism would provoke more radical reformers. At a religious conference with the Zwinglians in 1529, Melanchthon joined with Luther in opposing a union with Zwingli. With the protestation of the Lutheran princes at the Diet of Speyer (1529) and rejection of the Lutheran "Augsburg Confession" at Augsburg (1530), a separate Lutheran church finally emerged.

In Northern Europe, Luther appealed to the growing national consciousness of the German states because he denounced the Pope for involvement in politics as well as religion. Moreover, he backed the nobility, which was now justified to crush the Great Peasant Revolt of 1525 and to confiscate church property by Luther's Doctrine of the Two Kingdoms. This explains the attraction of some territorial princes to Lutheranism. However, the Elector of Brandenburg, Joachim I, blamed Lutheranism for the revolt and so did others. In Brandenburg, it was only under his successor Joachim II that Lutheranism was established, and the old religion was not formally extinct in Brandenburg until the death of the last Catholic bishop there, Georg von Blumenthal, who was Bishop of Lebus and sovereign Prince-Bishop of Ratzeburg.