John Deane Spence (7 December 1920 – 4 March 1986) was a British Conservative Party politician.
Spence was educated at Queen's University, Belfast and worked as a building and civil engineering contractor, merchant banker and farmer.
Spence contested Wakefield in 1964, and Sheffield Heeley in 1966. He was Member of Parliament for Sheffield Heeley from 1970 to 1974, Thirsk and Malton from 1974 to 1983, and Ryedale from 1983 until he died in office in 1986 aged 65. He was a member of the Speaker's panel of chairmen.