The Jeannie River is a river in Far North Queensland, Australia.
The headwaters of the river rise in the Great Dividing Range in the northern portion of the Cape York Peninsula in Kalpowar Aboriginal land northwest of and west of Starke. The river flows in a north easterly direction through mostly uninhabited country past Lagoon Prospect and then enters the Cape Melville National Park and eventually discharging into the Coral Sea almost adjacent to Howick Island. The river descends over its course.
The river has a catchment area of and takes in the wild rivers of the Jeannie, the Howick and Starke, of which an area of is composed of estuarine wetlands.