In 1850 Lopez succeeded in effecting his first descent upon the island. Having succeeded in baffling the vigilance of the United States government, an expedition, consisting of six hundred and fifty-two men, was embarked on board two sailing-vessels and the steamer Creole, which conveyed the general and his staff. In the beginning of July the sailing-vessels left New Orleans, with orders to anchor at Contoy, one of the Mugeres Islands, on the coast of Yucatan; the general followed, on the Creole, on the 7th. At the time when the troops were embarked on the Creole at Contoy, fifty-two of the number, who had been deceived as to the nature of the expedition, refused to follow the general, and were left on the island, with the intention of returning to the United States in the two schooners. General Lopez, after gaining some information from a fisherman he encountered, resolved to land at Cardenas, on the northern coast of the island, a hundred and twenty miles east of Havana. He calculated that he could surprise and master the garrison before the captain-general could possibly obtain intelligence of his departure from New Orleans. His plan was, to master the town, secure the authorities, intimidate the Spaniards, and then, sustained by the moral influence of victory, proceed to Matanzas by railroad.
Roncali, the captain-general, having received intelligence of the landing at Contoy, despatched several ships-of-war in that direction, to seize upon the general and his followers. The latter, however, escaped the snare, and effected his landing on the 19th. The garrison rushed to arms, and, while a portion of the troops, after immaterial loss, retired in good order to the suburbs, another, under the command of Governor Ceruti, intrenched themselves in the government-house, and gave battle to the invaders. After a sharp skirmish, the building being set on fire, they surrendered; the governor and two or three officers were made prisoners, and the soldiers consented to join the revolutionary colors! Meanwhile, a body of one hundred invaders seized upon the railroad station. The engines were fired up, and the trains made ready to transport the invading column to Matanzas.
But now came a pause. General Lopez, seeing that the native population did not respond to his appeal, knew that as soon as the news of the taking of Cardenas should be circulated, he would be in a very critical situation. In fact, the governor of Matanzas was soon on the march, at the head of five hundred men. General Armero sailed from Havana in the Pizarro, with a thousand infantry, while two thousand five hundred picked troops, under the command of General Count de Mirasol, were sent from Havana by the railroad. Lopez saw that it would be madness to wait the attack of these formidable columns, unsupported save by his own immediate followers, and accordingly issued his orders for the reëmbarkation of his band, yet without relinquishing the idea of landing on some more favorable point of the island.