The Archdiocese of Puebla de los Ángeles () is a Latin Church ecclesiastical territory or archdiocese of the Catholic Church. It is the oldest Catholic diocese in Mexico. It was established on October 13, 1525 as the "Diocese of Tlaxcala" and retained that name until it was elevated to an archdiocese in 1903. In 1959 a new Diocese of Tlaxcala was created and is suffragan to the Archdiocese of Puebla de los Ángeles.
A separate diocese seated in Mexico City was created in 1530 and replaced the Archdiocese of Seville in Spain as Tlaxcala's metropolitan see in 1546. While its place as Mexico's most important Catholic see was short-lived, the Archdiocese of Puebla de los Ángeles is one of the largest archdioceses in Mexico today. Now a metropolitan see itself, within the ecclesiastical province of Puebla de los Ángeles contains two suffragan dioceses: Huajuapan de León and Tehuacán.
Bishops
Ordinaries
Coadjutor bishop
José Ignacio Márquez y Tóriz (1934–1945)
Auxiliary bishops
Francisco Juan Leiza (de Leyva) (1739–1747) Miguel Anselmo Álvarez de Abreu y Valdéz (1749–1765), appointed Bishop of Antequera, Oaxaca José Ignacio Márquez y Tóriz (1934), appointed Coadjutor here Emilio Abascal y Salmerón (1953–1968), appointed Archbishop of Jalapa (Xalapa), Veracruz Ricardo Guízar Díaz (1970–1977), appointed Auxiliary Bishop of Aguascalientes Rosendo Huesca Pacheco (1970–1977), appointed Archbishop here Eugenio Andrés Lira Rugarcía (2011–2016), appointed Bishop of Matamoros, Tamaulipas Dagoberto Sosa Arriaga (2011–2013), appointed Bishop of Tlapa, Guerrero Tomás López Durán (2013– Rutilo Felipe Pozos Lorenzini (2013–2020), appointed Bishop of Roman Catholic Diocese of Ciudad Obregón