In Alabama, Interstate 20 (I-20) travels through the center of the state. It enters the state from Mississippi near Cuba, and travels northeastward through Tuscaloosa and Birmingham. At Birmingham, I-20 turns eastward and heads through Oxford before crossing the Georgia state line near Lebanon. Other cities on the route include Livingston, Bessemer, and Pell City.

For approximately , more than half its distance within the state, I-20 is concurrent with I-59 from the Mississippi state line to eastern Birmingham near Birmingham–Shuttlesworth International Airport. Mileage and exits on the concurrency are I-59's, although both highways have the same mileage for the Alabama concurrency.

Interstate 20 in Alabama

Route description

Western Alabama

After I-20/I-59 enters Alabama from Mississippi, they travel concurrently northeastward across the Tombigbee River and Black Warrior River delta country which is generally low-lying farmland until reaching Tuscaloosa. This area contains low population. U.S. Route 11 (US 11) parallels this route from Mississippi northeastward while it passes through small towns like York, Livingston, and Eutaw before reaching Tuscaloosa. From the Mississippi–Alabama state line to Tuscaloosa, I-20/I-59 is a four-lane route.

Interstate 20 in Alabama

At Tuscaloosa, the highway connects with I-359 which travels northward into downtown Tuscaloosa and to the University of Alabama. After the I-359 junction, the route widens to become six lanes. From Tuscaloosa to Birmingham, the highway continues on an east-northeast heading traveling through rolling forested terrain until reaching I-459 southwest of Bessemer. All of the stretch from Tuscaloosa to the I-459 junction near Bessemer is six lanes. This stretch also hosts the Mercedes auto plant which is a large employer of residents primarily from Jefferson, Tuscaloosa, and Bibb counties. I-459 travels east and then northeast around the southern periphery of the Birmingham area before reconnecting first with I-20 near Irondale and then terminating at I-59 near Trussville. I-422 (Birmingham Northern Beltline) is slated to connect to I-20/I-59 at the I-459 interchange; however, this project is still years away from completion.

Interstate 20 in Alabama

Birmingham

After passing the I-459 interchange, the highway continues northeast as a four-lane highway through the Birmingham suburbs of Bessemer, Hueytown, and Fairfield before widening after exit 118 in Fairfield to at least six lanes as the interstate approaches Birmingham near the Ensley community. Most of this stretch is through urban areas including passing near the U.S. Steel plant near Fairfield, and visible from the Interstate looking north and northwest are several smokestacks which is all that remain of several large steel mills that used to dominate the Ensley community of Birmingham.

As I-20/I-59 travels eastward just past the Arkadelphia Road exit in the East Thomas community, the highway rises to the top of East Thomas hill, giving eastbound travelers an excellent view of the downtown Birmingham skyline just before reaching the interchange with I-65.

As I-20/I-59 leaves the downtown area, the highway has an interchange with the Elton B. Stephens Expressway, also known locally as the Red Mountain Expressway, which travels south across the downtown area and into the southern Birmingham suburbs.

The highway continues east-northeast through downtown before reaching the Birmingham–Shuttlesworth International Airport where I-59 continues northeast toward Gadsden and I-20 turns eastward toward Atlanta.

Once I-20 turns away from I-59, it begins an eastbound journey toward Georgia. The first are a four-lane bridge of east Birmingham neighborhoods before reaching the shopping areas formerly known as Eastwood Mall and Century Plaza.

I-20 is a six-lane freeway from exit 132 to exit 162. This highway travels through rolling suburban country and crosses I-459 near Irondale.

"Bloody 20" The section of I-20 between Leeds and Pell City was one of the most dangerous stretches of Interstate Highway in Alabama. The terrain is significantly hilly as the route passing across the northeast to southwest ridges of the Appalachian Mountains. There are two significant uphill grades in each direction which slows down truck traffic. However, due to the heavy volume of truck traffic combined with speeding car traffic, accidents were frequent and sometimes deadly. This part of I-20 was sometimes called "Bloody 20". Between 2010 and 2014, work was completed to add one additional lane in each direction along I-20.