Jefferson School was an elementary school building located at Cape Girardeau, Missouri. It was built in 1904, and is a two-story, red brick and stone elementary school building with a raised sandstone foundation and hipped roof. It featured a bell tower rising above the roofline. It operated as the city's elementary school for African-American students from 1953–1955, when it closed. It was demolished on December 28, 2012.
It was listed on the National Register of Historic Places in 2009.