The Russian conquest of Siberia took place during 1580–1778, when the Khanate of Sibir became a loose political structure of vassalages that were being undermined by the activities of Russian explorers. Although outnumbered, the Russians pressured the various family-based tribes into changing their loyalties and establishing distant forts from which they conducted raids. It is traditionally considered that Yermak Timofeyevich's campaign against the Siberian Khanate began in 1580. The annexation of Siberia and the Far East to Russia was resisted by local residents and took place against the backdrop of fierce battles between the indigenous peoples and the Russian Cossacks, who often committed atrocities against the indigenous peoples.

Conquest of the Khanate of Sibir

The Russian conquest of Siberia began in July 1580 when some 540 Cossacks under Yermak Timofeyevich invaded the territory of the Voguls, subjects to Kuchum Khan, ruler of the Sibir Khanate. They were accompanied by some Lithuanian and German mercenaries and prisoners of war. Throughout 1581, this force traversed the territory known as Yugra and subdued Vogul and Ostyaks towns. At this time, they also captured a tax collector of Kuchum Khan.

Russian conquest of Siberia

Following a series of Tatar raids in retaliation against the Russian advance, Yermak's forces prepared for a campaign to take Qashliq, the Siberian capital. The force embarked in May 1582. After a three-day battle on the banks of the Irtysh River, Yermak was victorious against a combined force of Kuchum Khan and six allied Tatar princes. On 29 June, the Cossack forces were attacked by the Tatars but again repelled them.

Russian conquest of Siberia

Throughout September 1582, the Khan gathered his forces for a defense of Qashliq. A horde of Siberian Tatars, Voguls, and Ostyaks massed at Mount Chyuvash to defend against invading Cossacks. On 1 October, a Cossack attempt to storm the Tatar fort at Mount Chyuvash was held off. On 23 October, the Cossacks attempted to storm the Tatar fort at Mount Chyuvash for a fourth time when the Tatars counterattacked. More than a hundred Cossacks were killed, but their gunfire forced a Tatar retreat and allowed the capture of two Tatar cannons. The forces of the Khan retreated, and Yermak entered Qashliq on 26 October.

Russian conquest of Siberia

Kuchum Khan retreated into the steppes and over the next few years regrouped his forces. He suddenly attacked Yermak on 6 August 1584 in the dead of night and defeated most of his army. The details are disputed with Russian sources claiming Yermak was wounded and tried to escape by swimming across the Wagay River which is a tributary of the Irtysh River, but drowned under the weight of his own chain mail. The remains of Yermak's forces under the command of Mescheryak retreated from Qashliq, destroying the city as they left. In 1586, the Russians returned, and after subduing the Khanty and Mansi people through the use of their artillery they established a fortress at Tyumen close to the ruins of Qashliq. The Tatar tribes that were submissive to Kuchum Khan suffered from several attacks by the Russians between 1584–1595; however, Kuchum Khan would not be caught. Finally, in August 1598, Kuchum Khan was defeated at the near the Ob River. In the course of the fight, the Siberian royal family was captured by the Russians. However, Kuchum Khan escaped yet again. The Russians took the family members of Kuchum Khan to Moscow and there they remained as hostages. The descendants of the khan's family became known as the Princes Sibirsky and the family is known to have survived until at least the late 19th century.

Despite his personal escape, the capture of his family ended the political and military activities of Kuchum Khan and he retreated to the territories of the Nogai Horde in southern Siberia. He had been in contact with the tsar and had requested that a small region on the banks of the Irtysh River would be granted as his dominion. This was rejected by the tsar who proposed to Küçüm Khan that he come to Moscow and "comfort himself" in the service of the tsar. However, the old khan did not want to suffer from such contempt and preferred staying in his own lands to "comforting himself" in Moscow. Kuchum Khan then went to Bukhara and as an old man became blind, dying in exile with distant relatives sometime around 1605.