In 1872, Greeley became the Republican who was a candidate of the Democratic party for the presidency, and was defeated by Grant. Doubtless he was actuated by the highest sense of duty. He took the stump and spoke in every great city in the North and South, without swerving a hair's breadth in his pacific attitude towards the South, or in his championship of the coloured race. His great work, "The American Conflict," on which he spent ten hours a day for many, many months, had made Greeley a master of all the facts bearing upon the reconciliation of the North and South. He showed almost superhuman endurance during that intense campaign. But Grant had captured the imagination of the people. The old soldiers voted as one solid band, the Republican party was looked upon as the saviour of the nation, and the people doubted Mr. Greeley's fitness for the presidency in a national crisis. He was defeated in November, and went home to watch over his wife during her illness and death. Just before she died, he wrote a friend saying: "I am a broken old man; I have not slept one hour in twenty-four; if she lasts, poor soul, another week, I shall go before her." Sleeplessness brought on brain fever, his old enemy, and on November 29th, the worn-out editor fell on sleep.
His fellow countrymen wakened to realize that the great tribune of the people had left the country poor. His own city rose as one man, in mood of profound grief and affectionate admiration and sympathy. His body lay in state in our city hall the long day through. The poor poured by in unending column, to pay their last tribute to a man who had never betrayed the people. The funeral services were attended by the president and vice-president of the United States, the president-elect, and numerous officials and citizens of distinction. Mr. Beecher made one address and then Greeley's pastor, Dr. Chapin, spoke. Men forgot the wreck of his political fortunes and the tragedy of his later career. He expressed the ambition of his life in the wish "that the stone which covers my ashes may bear to future eyes the still intelligible inscription: 'Founder of the New York Tribune.'"
A Universalist in his religious faith, Horace Greeley believed that right was stronger than wrong, good more powerful than evil, and that there will be in eternal ages no endless perdition for the evil ones of earth, but that God and all the resources of His power and love will here or there compel every knee to bow and every will surrender to the will divine. He earned the right to say at the end of his noble career, "I have been spared to see the end of giant wrongs that I once deemed invincible in this country, and to note the silent upspringing and growth of principles and influences which I hail as destined to root out some of the most flagrant and pervading influences that remain. So, looking calmly, yet humbly, for that close of my mortal career which cannot be far distant, I reverently thank God for the blessings vouchsafed me in the past; and with an awe that is not fear, and a consciousness of demerit which does not exclude hope, await the opening before my steps of the gates of the Eternal World."