His worst mistake was the policy he adopted with regard to the family of the Incas. He desired to establish the position of the King of Spain without a rival. He, therefore, sought to malign the preceding dynasty, persecuted the descendants of the Incas, and committed one act of cruel injustice.
When Atahualpa put his half-brother Huascar, the last reigning Inca, to death, there remained three surviving sons of their father the great Inca Huayna Ccapac, named Manco, Paullu, and Titu Atauchi, and several daughters. After his occupation of Cuzco, Pizarro acknowledged Manco Inca as the legitimate successor of his brother Huascar, and he was publicly crowned, receiving all the insignia on March 24th, 1534. He escaped from the Spaniards and besieged them in Cuzco at the head of a large army. Forced to raise the siege he established his head-quarters at Ollantay-tampu, where he repulsed an attack led by Hernando Pizarro. He was, however, defeated by Orgoñiez, the lieutenant of Almagro, and took refuge in the mountainous province of Vilcapampa on the left bank of the Vilcamayu. From thence he made constant attacks on the Spaniards, maintaining his independence in this small remnant of his dominions. Some of the partisans of Almagro took refuge with him, and he was accidentally killed by one of them in 1544, after a not inglorious reign of ten years.
He left two legitimate sons, named Sayri Tupac and Tupac Amaru, by his wife and niece the Princess Ataria Cusi Huarcay, daughter of his ill-fated brother Huascar. This marriage was legalized by a bull of Pope Paul III in the time of the Viceroy Marquis of Cañete, 1555--1561. He had also an illegitimate son named Cusi Titu Yupanqui, and a daughter named Maria Tupac Usca, married to Don Pedro Ortiz de Orue, one of the first conquerors[9].
[Note 9: Diego Ortiz de Orue was born in the village of Getafe, near Madrid. He went out to Peru in 1559, and at once began to study the Quichua language. He was _encomendero_ of Maras, a village overlooking the valley of Yucay. By the Inca princess he had a daughter named Catalina married to Don Luis Justiniani of Seville, descended from the Genoese family. Their son Luis was the grandfather of Dr Justo Pastor Justiniani who married Manuela Cataño, descended from Tupac Inca Yupanqui. Their son Don Pablo Justiniani was Cura of Laris until his death in 1858, and was a great depository of Inca lore. He had a very early copy of the Inca drama of Ollanta.]