Lord Derby was ably seconded if not directed by his wife; indeed she was the stronger character of the two. She was the daughter of Claude de la Tremoille, Duc de Thouars, and grand-daughter of William the Silent, Prince of Orange. On coming to England her mother had endeavoured, though without success, to have her attached to the household of the Queen. After the outbreak of the war it would seem as if Lady Derby had endeavoured to secure herself against possible reverses of the royalist cause; but she showed no wavering afterwards, and her defence of Lathom House in 1644 was the one conspicuous success of the royalist cause in Lancashire. After her husband's death she was with difficulty persuaded to surrender the Isle of Man when all other resistance had come to an end.[30]
Next in rank was Richard, Second Viscount Molyneux, the son of Sir Richard Molyneux of Sefton, who had been created in 1628 Viscount Molyneux of Maryborough in the Irish peerage. He was only 19 at the outbreak of the Civil War, and though he took some part in the fighting he was not personally of much advantage to his party in Lancashire. There are several references to him by contemporaries as Lord Derby's son-in-law, the fact being that a 'child marriage' was contracted in 1639 between Molyneux and Henrietta Maria, eldest daughter of Lord Derby, who was then only 9 years old. There was some legal doubt as to whether the marriage was not actually valid; but it was never consummated, though apparently the matter was still in abeyance in 1650 when Molyneux received permission to send messengers to the Isle of Man to receive the lady's answer. He died in July, 1654, and was succeeded in the title by his brother Caryll, who also had taken some little part in the war in Lancashire.

Molyneux surrendered after the capture of Ludlow and took the Covenant and the Negative Oath in August 1646. His fine at a sixth was £9,037.[31]

By far the ablest of the Lancashire Royalists, and next to Derby the most prominent, was Thomas Tyldesley. He was a Roman Catholic, of a younger branch of the Tyldesleys of Tyldesley, and resided at Myerscough Hall near Garstang. He married Bridget Standish, whose mother was sister of Richard, first Viscount Molyneux, and was therefore a cousin by marriage of the second Viscount. He is better known as Sir Thomas Tyldesley, being knighted for his services when with the Queen at Burton Bridge in July, 1643. Tyldesley was concerned in all the early Royalist movements in Lancashire. He was in command at Liverpool when it was first surrendered to the Parliament in 1643; and attended Rupert in the following year at the sack of Bolton, the recapture of Liverpool, and the relief of Lathom House. When the Royalist cause in Lancashire was finally lost, Tyldesley was active in other parts of the country, and was three times taken prisoner. He was Governor of Lichfield when that town was captured in 1646; he then served in Ireland, and took part in Hamilton's invasion in 1648. Afterwards Tyldesley found refuge in the Isle of Man, joined Derby's invasion in 1651, and was killed at the Battle of Wigan Lane. He was a good specimen of the best type of chivalrous Cavalier. He never compounded for his estates, and considering the very prominent part which he took in the War, the ruling powers treated him very lightly, for no forfeiture is known to have followed his death.[32]






