Route 252 or Highway 252 may refer to:
Canada
Manitoba Provincial Road 252
Nova Scotia Route 252
Costa Rica
National Route 252
Japan
Japan National Route 252
United States
Arkansas Highway 252
California State Route 252 (former) Georgia State Route 252 Indiana State Road 252 Iowa Highway 252 (former) K-252 (Kansas highway) Kentucky Route 252 Minnesota State Highway 252 Montana Secondary Highway 252 New Mexico State Road 252 New York State Route 252 New York State Route 252A Ohio State Route 252 Pennsylvania Route 252 South Carolina Highway 252 Tennessee State Route 252 Texas State Highway Loop 252 Texas State Highway 252 (former) Farm to Market Road 252 (Texas) Utah State Route 252 Virginia State Route 252 West Virginia Route 252 Wyoming Highway 252 Territories: Puerto Rico Highway 252