Roanoke may refer to:
Places
Roanoke Colony, a former English colony that mysteriously disappeared
Roanoke Island, the location of the Roanoke colony in present-day North Carolina
Roanoke River, flowing through Virginia and North Carolina and emptying into Albemarle Sound near Roanoke Island Roanoke Valley, part of the Great Appalachian Valley near the headwaters of the Roanoke River in Virginia Roanoke, Alabama Roanoke, Georgia Roanoke, Illinois Roanoke, Indiana Roanoke, Louisiana Roanoke, Missouri Roanoke, Texas Roanoke, Virginia, the largest US city named Roanoke Roanoke County, Virginia Roanoke, West Virginia Roanoke Rapids, North Carolina Randolph, Virginia, formerly called Roanoke
Other uses
Roanoke tribe, a Carolina Algonquian-speaking tribe in western North Carolina
Roanoke Park (Seattle), a park in Seattle, Washington
USS Roanoke, various USN vessels named Roanoke
Roanoke (ship), an American ship (1892–1905) Roanoke College, a private liberal arts college located in Salem, Virginia Neo Roanoke, a fictional character in Mobile Suit Gundam SEED Destiny, an anime series Roanoke Building, a building in Chicago, Illinois American Horror Story: Roanoke, the sixth season of the television series American Horror Story Roanoke Station (disambiguation)