Mario Rodríguez may refer to:

Sports

Association football

Mario Rodríguez (footballer, born 1937) (1937–2015), Argentine footballer

Mario Rodríguez (footballer, born 1972), Peruvian footballer

Mario César Rodríguez (born 1975), Honduran footballer

Mario-Ernesto Rodríguez (born 1976), Uruguayan-Italian footballer

Mario Rodríguez (footballer, born 1978), Mexican footballer

Mario Rodríguez (footballer, born 1981), Guatemalan footballer

Mario Rodríguez (footballer, born 1991), Mexican footballer

Mario Rodríguez (soccer, born 1994), American soccer player for Dynamo Dresden

Mario Rodríguez (footballer, born 1995), Mexican footballer

Mario Rodríguez (footballer, born 1997), Spanish footballer

Other sports

Mario Rodríguez (baseball) (1909–?), Cuban baseball player

Mario Rodríguez (weightlifter), Dominican Republic Olympic weightlifter

Mario Rodriguez (fencer) (born 1959), American Paralympic fencer

Mario Rodríguez (boxer) (born 1988), Mexican professional boxer

Others

Mario Rodríguez Cobos (1938–2010), Spanish-Argentine writer and spiritual leader

Mario Rodríguez