In enzymology, a biotin—[acetyl-CoA-carboxylase] ligase () is an enzyme that catalyzes the chemical reaction
ATP + biotin + apo-[acetyl-CoA:carbon-dioxide ligase (ADP-forming)] AMP + diphosphate + [acetyl-CoA:carbon-dioxide ligase (ADP-forming)]
The 3 substrates of this enzyme are ATP, biotin, and apo-[acetyl-CoA:carbon-dioxide ligase (ADP-forming)], whereas its 3 products are AMP, diphosphate, and acetyl-CoA:carbon-dioxide ligase (ADP-forming).
This enzyme belongs to the family of ligases, specifically those forming generic carbon-nitrogen bonds.
This enzyme participates in biotin metabolism. This protein may use the morpheein model of allosteric regulation.
Nomenclature
The systematic name of this enzyme class is biotin:apo-[acetyl-CoA:carbon-dioxide ligase (ADP-forming)] ligase (AMP-forming). Other names in common use include: biotin-[acetyl-CoA carboxylase] synthetase, biotin-[acetyl coenzyme A carboxylase] synthetase, acetyl coenzyme A holocarboxylase synthetase, acetyl CoA holocarboxylase synthetase, biotin:apocarboxylase ligase, biotin holoenzyme synthetase, and HCS.