I should like here to recall to your notice the work of an English observer, Dr. E. Montgomery of St. Thomas's { 88} Hospital, which was published as long ago as 1865. This work was recently brought to my notice by the kindness of Professor Baumler of Freiburg. He says: "Crystals are not strangers in the organic world. Many organic compounds are able to assume crystalline forms under certain conditions. Rainey has shown that many shells consist of globular crystals _i.e._ of mineral substances made to crystallize by the influence of viscid material." In this connection I may also mention the interesting work of Otto Lehmann of Karlsruhe on liquid crystals.
In conclusion, we may recall the words of Schwann himself, the originator of the cell theory: "The formation of the elementary shapes of an organism is but a crystallization of substances capable of imbibition. The organism is but an aggregate of such imbibing crystals."
In 1873, Hermann Fol, writing of the eggs of Geryonia, thus describes the phenomenon of karyokinesis: "On either side of the residue of the nucleus there appears a concentration of plasma, thus forming two perfectly regular star-like figures, whose rays are straight lines of granulations. There are other curved rays which pass from one star or centre of attraction to the other. The whole figure is extraordinarily distinct, recalling in a striking manner the arrangement of iron filings surrounding the poles of a magnet. Sachs' theory is that the division of the nucleus is caused by centres of attraction, and I agree with him, not on theoretical grounds, but because I have actually seen these centres of attraction."
Since the discovery of Hermann Fol, a great number of explanations have been given, all of them theoretical, to account for the figures and phenomena of karyokinesis. Many of these so-called explanations are mechanical, while others invoke the aid of magnetism or electricity to account for the resemblance of the figures of karyokinesis to the magnetic or electric phantom or spectre. Among the authors who have dealt with this question we may mention Hartog of Cork, Gallardo of Buenos Ayres, and Rhumbler of Göttingen.
In 1904 I presented to the Grenoble Congress, and in 1906 to the Lyons Congress, a series of photographs and preparations of experimental karyokinesis. I showed how, in a solution analogous to that found in the natural cell, the simple processes of liquid diffusion, without the intervention of magnetism or electricity, may reproduce with perfect accuracy and in their normal sequence the whole of the movements and { 90} figures which characterize the phenomenon of karyokinesis. This experiment consists not merely in the production of a certain figure, such as is obtained in the magnetic spectre, but in the reproduction of the movement itself, and of all the successive forms which are seen in the natural phenomenon. These are evolved before the eyes of the spectator in their regular order and sequence.