Frances Separovic (born 1954) is a biophysical chemist, Distinguished Professor Emeritus of Chemistry, Deputy Director of the Bio21 Institute and former Head of the School of Chemistry at the University of Melbourne, where she taught physical chemistry and graduate students in her field. She is credited with developing a technique which utilises nuclear magnetic resonance spectroscopy (NMR) to study peptides in aligned lipid bilayers, and has applications in the study of the structure of membrane proteins and their effects on the membrane. Her current research concerns 'the structure and interactions of amyloid peptides from Alzheimer's disease, pore-forming toxins and antibiotic peptides in model biological membranes'.
Early life
Franica Šeparović was born in the Federal People's Republic of Yugoslavia, People's Republic of Croatia and emigrated to Australia with her family in 1957. They settled in Broken Hill, western New South Wales. Separovic excelled in school and she was awarded both a Commonwealth and teacher's scholarship; she began tertiary studies at the University of Sydney, but soon left to work at the Commonwealth Scientific and Industrial Research Organisation (CSIRO). In addition to work and study, Separovic was also a young mother.
Early career and academic achievements
Separovic's career in science began as a Technical Assistant at a CSIRO microbiology lab (1972–78) 'counting colonies' and 'doing the washing up'. Adept at these basic tasks, she habitually finished her work early and went in search of more to do. Her capacity with mathematics recommended her to a section of the department involved in modelling lipid membranes, and trying to discover why they leak. This was the project upon which Separovic first encountered an NMR instrument – at the time (the 70s) a new technique – which now plays such a major role in her research. It was here, too, that she made her first contribution to a scientific paper: using her aptitude for mathematics to determine via 'simple geometry' the smallest possible radius of a vesicle which it is possible to make (10-nanometers), solving a contemporaneous argument within the scientific community.
In 1978 Separovic completed a Technical Certificate in Biology at Sydney Technical College, and continued to work at the CSIRO as a Technical Officer while studying part-time on a Bachelor of Arts at Macquarie University, with majors in Mathematics and Physics. She completed her undergraduate degree in 1984, at which time she became an Experimental Scientist at CSIRO; in 1986 she finished an Honours qualification in Physics (also at Macquarie University). Between 1986 and 1992, in addition to being a single parent and working full-time at the CSIRO, she completed a PhD (part-time) in Physics at the University of New South Wales. Following a post-doctoral fellowship at the National Institutes of Health (Bethesda, USA), Frances returned briefly to CSIRO before moving to the University of Melbourne as an Associate Professor & Reader in 1996.
Later career and public recognition
In 2005, Separovic became the first woman to be appointed to a professorship in chemistry in Victoria and was Head of School of Chemistry, University of Melbourne (2010–2016). She is currently Professor of Chemistry at the Bio21 Institute, Foreign Secretary of the Australian Academy of Science, member of the Science Board of International Union of Pure and Applied Chemistry (IUPAC) and Advisory Committee of InterAcademy Partnership (AIP), and Past-President of the Biophysical Society; and was a member of Council of International Union for Pure and Applied Biophysics (IUPAB), President of the Australian & New Zealand Magnetic Society for Resonance (ANZMAG), Treasurer of the Royal Australian Chemical Institute(RACI), President of the Australian Society for Biophysics, and chaired the board of the Centre for Chemistry and Biotechnology at Deakin University. She has been on the editorial board of Biochimica et Biophysica Acta, an editor of European Biophysics Journal and a member of the editorial advisory board of Accounts of Chemical Research and Chemical Reviews.