The 2010 season for began in January with the Tour Down Under and ended in October at the Giro di Lombardia. As a UCI ProTour team, they were automatically invited and obliged to attend every event in the ProTour. The team looks to remain as one of the world's foremost in the spring classics. Its ridership is mostly unchanged from 2009, in spite of an offseason attempt to sign reigning Tour de France champion Alberto Contador.
2010 roster
Ages as of January 1, 2010.
Riders who joined the team for the 2010 season
Riders who left the team during or after the 2009 season
One-day races
Spring classics
Fall races
Stage races
After beginning their season at the Tour Down Under with no victories, Quick Step then entered the Tour of Qatar with two-time defending champion Boonen leading their squad. Boonen won two stages in the race, but a two-man breakaway in the race's second stage proved critical, as it afforded Wouter Mol and Geert Steurs the top two steps on the podium by more than a minute over the rest of the field. Boonen finished third overall.
Grand Tours
Giro d'Italia
Quick Step came to the Giro with a squad headed by Cataldo. Seeldraeyers, who had won the youth classification in the 2009 Giro d'Italia, was kept off the squad in favor of the Tour de France. Weylandt was included with sprint victories in mind.
In stage 3, the second of two road race stages in the Netherlands, Weylandt was successful at avoiding crashes, including one with left to race that made for a selection of just 29 riders finishing the stage together. Weyldant sprinted Graeme Brown and Robert Förster to take the stage win. After the transfer to Italy, the squad finished in 16th place in the stage 4 team time trial, finishing with six riders 2'15" off the pace of stage winners . The squad was again active in stage 5. Pineau followed an early morning move from rider Yukiya Arashiro, and they, along with ' Julien Fouchard formed the day's breakaway. The stage was flat, and in the final kilometers the sprinters' teams came to the front of the peloton to try to catch them. They did not time their move properly, however, and the three stayed by a margin of four seconds. Pineau won the sprint for the stage, and took the red jersey as points classification leader with this result.
The squad was largely quiet for the remainder of the Giro. Weylandt took seventh in a more full field sprint in stage 9. In stage 11, when 50 riders formed the day's breakaway and the favorites lost more than 13 minutes, Cataldo nearly took the squad's third victory. He and Pineau had both made the selection, but only Cataldo stayed at the front of the race toward the stage's end. Unable to bridge up to an attacking Evgeni Petrov in the stage's final kilometer, Cataldo was second on the day. Pineau was third in the stage 12 group sprint, taking the red jersey again for two days with this result. Samoilau rode the Monte Grappa climb in stage 14 with the second group on the road, leading them across the finish line 2'25" back of stage winner Vincenzo Nibali, for sixth on the day. Cataldo was ninth-best in the climbing time trial to Plan de Corones two stages later. In stage 19, Samoilau again led his group across the line, this time the third group on the road, for ninth place. Samoilau was the squad's highest-placed rider in the final overall standings, in 39th place at a deficit of one hour and 46 minutes to Giro champion Ivan Basso. Pineau won the Premio della Fuga classification for most kilometers spent in a breakaway of ten or fewer riders. The squad was 15th in the Trofeo Fast Team standings and 13th in the Trofeo Super Team.
Tour de France
Boonen intended to start the Tour de France, but had to pull out with a knee injury exacerbated in the Tour de Suisse. Lefevere had hoped to replace Boonen with Weylandt, but the young sprinter was not on the 15-name list Lefevere had first submitted to Tour organizers ASO, so he was ineligible. Reda took Boonen's place at the Tour's start. The squad also included Chavanel, coming off a lackluster season to date which included a fractured skull sustained at Liège–Bastogne–Liège, and Pineau, coming off a strong Giro d'Italia which included a stage win. Seeldraeyers, best young rider at the 2009 Giro d'Italia, was the team's only general classification rider, but they did not expect him to be a serious contender.