Canada competed at the 2012 Summer Paralympics in London, United Kingdom, from 29 August to 9 September 2012. A total of 145 athletes were sent by the Canadian Paralympic Committee to compete in 15 sports. The country won 31 medals in total and finished twentieth in the medals table, below the CPC's goal on a top eight finish in total gold medals. The total medals and total golds are the lowest totals for Canada since the 1972 Games.
Medalists
Archery
Men
|-
|align=left|Norbert Murphy
|align=left|Individual compound W1
|623
|6
|
|W 6–2
|W 6–0
|L 7–3
|W 6–1
|
|-
|align=left|Kevin Evans
|align=left rowspan="2"|Individual compound open
|626
|25
|W 6–4
|L 6–4
|colspan="4"| did not advance
|-
|align=left|Bob Hudson
|629
|23
|L 6–0
|colspan="5"| did not advance
|}
Women
|-
|align=left|Karen van Nest
|align=left|Individual compound open
|643
|6
|
|L 6–5
|colspan=4| did not advance
|-
|align=left|Lyne Tremblay
|align=left|Individual recurve W1/W2
|423
|20
|L 6–0
|colspan=5| did not advance
|}
Athletics
Men's track
Men's field
Women's track
Boccia
Individual
Pairs and teams
Cycling
Road
Track
Goalball
Men's tournament
Group B
Women's tournament
Group D
Quarter-final
Judo
Rowing
Qualification legend: FA=Final A (medal); FB=Final B (non-medal); R=Repechage
Sailing
Shooting
Swimming
Men
Women
Wheelchair basketball
Canada have qualified one men's team and one women's team in wheelchair basketball through their results at the 2010 Wheelchair Basketball World Championship. Competing athletes are given an eight-level-score specific to wheelchair basketball, ranging from 0.5 to 4.5 with lower scores representing a higher degree of disability. The sum score of all players on the court cannot exceed 14.