Hudspeth is a surname and may refer to:
A. James Hudspeth, F.M. Kirby Professor at Rockefeller University
Adam Hudspeth (1836–1890), Canadian lawyer and politician
Charles Hudspeth (activist) (1918–1999), civil rights leader from San Antonio, Texas Charles Hudspeth (convict), American man convicted of murder in Marion County, Arkansas in 1887 Cindy Lee Hudspeth (1958–1978), American murder victim Claude Benton Hudspeth (1877–1941), American rancher, lawyer, and statesman from El Paso, Texas Frank Hudspeth (1890–1963), English footballer, played for Newcastle United for 19 years, captain 1923–1926 Harry Lee Hudspeth (born 1935), United States federal judge Mark Hudspeth (born 1968), current head football coach at the University of Louisiana at Lafayette Robert Hudspeth (1894–1935), American Negro League baseball player Tommy Hudspeth, football coach at both the collegiate and professional levels