Type I cytokine receptors are transmembrane receptors expressed on the surface of cells that recognize and respond to cytokines with four α-helical strands. These receptors are also known under the name hemopoietin receptors, and share a common amino acid motif (WSXWS) in the extracellular portion adjacent to the cell membrane. Members of the type I cytokine receptor family comprise different chains, some of which are involved in ligand/cytokine interaction and others that are involved in signal transduction.
The common cytokine-binding domain is related to the Fibronectin type III domain.
Signal transduction chains
The signal transducing chains are often shared between different receptors within this receptor family. The IL-2 receptor common gamma chain (also known as CD132) is shared between: IL-2 receptor IL-4 receptor IL-7 receptor IL-9 receptor IL-13 receptor IL-15 receptor IL-21 receptor The common beta chain (CD131 or CDw131) is shared between the following type I cytokine receptors: GM-CSF receptor IL-3 receptor IL-5 receptor. The gp130 receptor (Glycoprotein 130) (also known as gp130, IL6ST, IL6-beta or CD130) is shared between: IL-6 receptor IL-11 receptor IL-12 receptor IL-27 receptor Leukemia inhibitory factor receptor Oncostatin M receptor
Examples
Type I cytokine receptors include interleukin receptors, colony stimulating factor receptors and other cytokine receptors