The person beyond all comparison most dreaded and detested by Henry at this juncture was his cousin Reginald Pole, for whom when a youth he had conceived a warm affection, whose studies he had encouraged by the gift of a deanery and the hope of further church-preferment, and of whose ingratitude he always believed himself entitled to complain. It was the long-contested point of the lawfulness of Henry's marriage with his brother's widow, which set the kinsmen at variance. Pole had from the first refused to concur with the university of Paris, in which he was then residing, in its condemnation of this union: afterwards, alarmed probably at the king's importunities on the subject, he had obtained the permission then necessary for leaving England, to which he had returned, and travelled into Italy. Here he formed friendships with the most eminent defenders of the papal authority, now incensed to the highest degree against Henry, on account of his having declared himself head of the English church; and both his convictions and his passions becoming still more strongly engaged on the side which he had already espoused, he published a work on the unity of the church, in which the conduct of his sovereign and benefactor became the topic of his vehement invective.
The offended king, probably with treacherous intentions, invited Pole to come to England, and explain to him in person certain difficult passages of his book: but his kinsman was too wary to trust himself in such hands; and his refusal to obey this summons, which implied a final renunciation of his country and all his early prospects, was immediately rewarded by the pope, through the emperor's concurrence, with a cardinal's hat and the appointment of legate to Flanders. But alarmed, as well as enraged, at seeing the man whom he regarded as his bitterest personal enemy placed in a situation so convenient for carrying on intrigues with the disaffected papists in England, Henry addressed so strong a remonstrance to the governess of the Netherlands, as caused her to send the cardinal out of the country before he had begun to exercise the functions of his legantine office.
From this time, to maintain any intercourse or correspondence with Pole was treated by the king as either in itself an act of treason, or at least as conclusive evidence of traitorous intentions. He believed that the darkest designs were in agitation against his own government and his son's succession; and the circumstance of the cardinal's still declining to take any but deacon's orders, notwithstanding his high dignity in the church, suggested to him the suspicion that his kinsman aimed at the crown itself, through a marriage with the princess Mary, of whose legitimacy he had shown himself so strenuous a champion. What foundation there might be for such an idea it is difficult to determine.