Town Creek may refer to the following places in the United States:
Communities
Town Creek, Alabama, a town in Lawrence County
Town Creek, Dallas, Texas, a neighborhood in the Lake Highlands area
Town Creek, Maryland, an unincorporated community in Allegany County
Waterways
Town Creek (Mississippi), a tributary stream of the Tombigbee River
Town Creek (Chestatee River tributary), a tributary of Tesnatee Creek in Georgia
Town Creek (Talking Rock Creek tributary), a stream in Georgia
Town Creek (Withlacoochee River tributary), a stream in Georgia
Town Creek (Patuxent River), a tributary of the Patuxent River in Saint Mary's County, Maryland Town Creek (Potomac River), a tributary of the Potomac River in Maryland and Pennsylvania Town Creek (Tred Avon River), a tributary of the Tred Avon River, Talbot County, Maryland