Twenty One Pilots is an American musical duo from Columbus, Ohio, consisting of frontman Tyler Joseph and bandmate Josh Dun. The band has received 42 awards from a total of 145 nominations.
Alternative Press Music Awards
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| rowspan="4" | 2014
| Vessel
| Album of the Year
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| rowspan="2" | Twenty One Pilots
| Breakthrough Band
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| Best Live Band
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| Josh Dun
| Best Drummer
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| rowspan="3" | 2015
| rowspan="4" | Twenty One Pilots
| Best Live Band
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| Most Dedicated Fans
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| Tumblr Fandom of the Year
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| rowspan="3" | 2016
| Artist of the Year
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| Blurryface
| Album of the Year
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| "Stressed Out" | Best Music Video | |- | rowspan="1" | 2017 | Twenty One Pilots | Most Dedicated Fans | |- |}
American Music Awards
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|rowspan="2" | 2016
|rowspan="4" | Twenty One Pilots
| Favorite Duo or Group – Pop/Rock
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|rowspan="3" | Favorite Artist – Alternative Rock
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| rowspan="1" | 2017
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| 2020
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ARIA Music Awards
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|2016
| Twenty One Pilots
| Best International Artist
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BBC Radio 1
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|2018
| Jumpsuit
| Hottest Record of the Year
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Billboard Awards
Billboard Music Awards
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| rowspan="4"| 2016
| rowspan="2"| Twenty One Pilots
| Top Duo/Group
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| Top Rock Artist
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| Blurryface
| Top Rock Album
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| "Stressed Out" | Top Rock Song | |- | rowspan="17"| 2017 |rowspan="9" | Twenty One Pilots | Top Artist | |- | Billboard Chart Achievement | |- | Top Duo/Group | |- | Top Billboard 200 Artist | |- | Top Hot 100 Artist | |- | Top Song Sales Artist | |- | Top Radio Songs Artist | |- | Top Streaming Artist | |- | Top Rock Artist | |- | rowspan="2"| Blurryface | Top Billboard 200 Album | |- | Top Rock Album | |- | rowspan="4"| "Heathens" | Top Hot 100 Song | |- | Top Selling Song | |- | Top Streaming Song (Video) | |- | rowspan="3"| Top Rock Song | |- | "Stressed Out" | |- | "Ride" | |- | rowspan="2"| 2019 | Twenty One Pilots | Top Rock Artist | |- | Trench | Top Rock Album | |- | rowspan="3"| 2020 | "Chlorine" | rowspan="2"| Top Rock Song | |- | "The Hype" | |- | rowspan="3"| Twenty One Pilots | rowspan="3"| Top Rock Artist | |- | 2021 | |- | rowspan="2"|2022 | |- | “Scaled and Icy” | Top Rock Album | |}
Billboard Touring Awards
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| 2016
| Twenty One Pilots
| Breakthrough Artist
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BMI Awards
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| rowspan="2"| 2017
| rowspan="2"| Award Winning Songs
| "Ride" | |- | "Stressed Out" | |- | rowspan= | 2021 | rowspan="2" | Songwriters & Publishers of the Most-Performed Songs of the Year | "Level of Concern" | |- | rowspan= | 2023 | "Saturday" | |- |}
Brit Awards
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| 2017
|rowspan="2" | Twenty One Pilots
|rowspan="2" | International Group
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| 2019
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Echo Awards
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| rowspan="2"|2017
| rowspan="2" | Twenty One Pilots
| Best International Newcomer
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| Best International Rock/Pop Group
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GAFFA Awards
GAFFA Awards (Denmark) Delivered since 1991, the GAFFA Awards are a Danish award that rewards popular music by the magazine of the same name.
! |- | 2016 | Twenty One Pilots | Best Foreign New Act | | style="text-align:center;" | |- |}
Grammy Awards
Note: "Heathens" was nominated for Best Rock Song and Best Song Written for Visual Media in 2017, which are only presented to the songwriter of the song, Tyler Joseph.
Note: "Jumpsuit" was nominated for Best Rock Song in 2019 which are only presented to the songwriter of the song, Tyler Joseph.