The 2005-06 Premier Reserve League season was the seventh since its establishment, and the last to feature more than 20 teams. The Northern League was won by Manchester United Reserves, while the Southern League was won by Tottenham Hotspur Reserves.
League table
Reserve League North
Reserve League South
Pld = Matches played; W = Matches won; D = Matches drawn; L = Matches lost; F = Goals for; A = Goals against; GD = Goal difference; Pts = Points
North/South Play-off Shield
The north–south play-off was won by Manchester United Reserves, who beat Tottenham Hotspur Reserves 2–0 at Old Trafford on 4 May 2006.